嗜好性研究 – 有限会社メルクエスト


Warning: Invalid argument supplied for foreach() in /home/kir604242/public_html/wp-content/themes/melquest/taxonomy-cat_thesis.php on line 5

ドラム式運動負荷装置ラット用強制回転かご

FWS-3006/FWS-3002/FWS-3001

複数匹のラットを同時に運動させる装置です。ストレス負荷の目的でも利用できるため、代謝研究だけではなく、うつ病研究等、幅広くご利用いただけます。

データ取得システムただ今準備中です

時間生物学研究関連ただ今準備中です

排尿機能測定・尿代謝実験ただ今準備中です

筋力測定・身体機能マウス・ラット用握力測定装【実用新案取得済】

GPM-101B/GPM-101V

マウス・ラットの筋力を手軽に計測できる装置です。筋ジストロフィー、多発性筋などの研究にお使いいただけます。

【水平型握力測定装置】

SIRT1 deficiency interferes with membrane resealing after cell membrane injury
2019 Jun 26;14(6):e0218329. doi: 10.1371/journal.pone.0218329. eCollection 2019.
Daisuke FujiwaraNaotoshi IwaharaRio SeboriRyusuke Hosoda, Shun ShimohamaAtsushi KunoYoshiyuki Horio 

Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice
First published: DOI:10.1002/syn.21978
Kazumi Yoshizawa,Ayano Okumura,Kozue Nakashima,Tomoyo Sato,Tatsuya Higashi

Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed Investigations with a Selective Allosteric Metabotropic Glutamate Receptor 1 Antagonist, FTIDC [4-[1-(2-Fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide].

Akio Satow, Shunsuke Maehara, Satoko Ise, Hirohiko Hikichi, Miyuki Fukushima, Gentaroh Suzuki, Toshifumi Kimura, Takeshi Tanaka, Satoru Ito, Hiroshi Kawamoto and Hisashi Ohta

【縦型握力測定装置】

β-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice
Nutrients 2020, 12(8), 2180; https://doi.org/10.3390/nu12082180 Received: 9 June 2020 / Revised: 15 July 2020 / Accepted: 21 July 2020 / Published: 22 July 2020
Mari Noguchi Tomoya KitakazeYasuyuki KobayashiKatsuyuki MukaiNaoki HaradaRyoichi Yamaji

Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice
Scientific Reports 7, Article number: 42323 (2017) doi:10.1038/srep42323
Hikari Takeshita, Koichi Yamamoto, Satoko Nozato, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Ryohei Yamamoto, Yuki Imaizumi, Kazuhiro Hongyo, Serina Yokoyama, Masao Takeda, Ryosuke Oguro, Yoichi Takami, Norihisa Itoh, Yasushi Takeya, Ken Sugimoto, So-ichiro Fukada& Hiromi Rakugi

ロータロッド マウス用ロータロッド 5連

RTR-M5

マウス5匹同時に計測可能な回転棒テスト装置です。運動協調性の評価や運動学習に。

学習・記憶・行動科学受動的回避実験装置 (パッシブアボイダンスシステム)

MPB-M030/MPB-R020

抗健忘作用を目標とする抗認知症薬の薬効評価、記憶学習、学習行動の評価等にお使いください。

Ueno, H., Takahashi, Y., Suemitsu, S. et al. Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results. Sci Rep 10, 3509 (2020). 

Yoshiyuki Soeda Y, Tsuneki H, Muranaka H, Mori N, Hosoh S, Ichihara Y, Kagawa S, Wang Xu, Toyooka N, Takamura Y, Uwano T, Nishijo H, Wada T and Sasaoka T. Molecular Endocrinology 2010:24(10):1965-1977. The Inositol Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in Neuroprotection and Memory Function in Mouse Brain.

筋力測定・身体機能前肢機能測定用階段試験装置

SCT300 / SCT301

脳梗塞モデルのリハビリ効果の評価等に用いられています。マウス用とラット用がございます。

Abnormal Pyramidal Decussation and Bilateral Projection of the Corticospinal Tract Axons in Mice Lacking the Heparan Sulfate Endosulfatases, Sulf1 and Sulf2.
Satoshi Aizawa, Takuya Okada, Kazuko Keino-Masu, Tri Huu Doan, Tadachika Koganezawa, Masahiro Akiyama, Akira Tamaoka, and Masayuki Masu   Frontiers in Molecular Neuroscience 12:333 · January 2020

Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. Lee JK, Kim JE, Sivula M, Strittmatter SM. J Neurosci. 2004 Jul 7; 24(27):6209-17.

The staircase test of skilled reaching in mice. Baird AL, Meldrum A, Dunnett SB. Brain Res Bull. 2001 Jan 15; 54(2):243-50.

Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury.  J, Corbett D. J Neurosci. 2001 July 15; 21(14):5272-80

給餌制限・摂餌量測定摂餌制限機能付摂餌量測定装置

cFDM-300AS/cFDM-700AS

市販の固形飼料を用いてマウス・ラットの摂餌量が測定できます。テレメトリーに対応。生体リズムや肥満の研究に、ホームケージ活性を利用したマウスのスクリーニング等に御活用ください。

Diet Intake Control Is Indispensable for the Gluconeogenic Response to Sodium-Glucose Cotransporter 2 Inhibition in Male Mice
J Diabetes Investig. 2020 Jun 9. doi: 10.1111/jdi.13319. Online ahead of print
Emi Hashiuchi , Hitoshi Watanabe, Kumi Kimura, Michihiro Matsumoto Hiroshi Inoue, Yuka Inaba

Hepatic Gluconeogenic Response to Single and Long-Term SGLT2 Inhibition in Lean/Obese Male Hepatic G6pc-Reporter Mice
Endocrinology. 2019 Dec 1;160(12):2811-2824. doi: 10.1210/en.2019-00422
Yuka Inaba, Emi Hashiuchi, Hitoshi Watanabe, Kumi Kimura, Makoto Sato, Masaki Kobayashi, Michihiro Matsumoto, Tadahiro Kitamura, Masato Kasuga, Hiroshi Inoue

Time-dependent effects of ipragliflozin on behaviour and energy homeostasis in normal and type 2 diabetic rats continuous glucose telemetry analysis
SCIENTIFIC REPORT 7:11906 DOI:10.1038/s41598-017-12106-y
Hiroyuki Iuchi, Masaya Sakamoto, Daisuke Matsutani, Hirofumi Suzuki, Yosuke Kayama, Norihiko Takeda, Susumu Minamisawa&Kazunori Utsunomiya

シリンジポンプ自動注入ポンプ 1本架けタイプ

FP-1100/FP-1100W

外部制御機能付きのコストパフォーマンスの高いシリンジポンプです。プッシュのみ対応とプッシュ・プル対応タイプをご用意しております。

シリンジポンプ自動注入ポンプ 2本架けタイプ

FP-2100

シリンジ2本架けタイプです。多数本対応をご希望の方向けに、6本架けタイプもご用意しております。100ステップまでの加減速プログラムに対応。

シリンジポンプ自動注入ポンプ ハイパワー 2本架けタイプ

FP-2200

100mlのシリンジ2本を同時に押し出すことができるハイパワーモーターを搭載。

シリンジポンプ 連続注入連続注入対応ポンプ

FP-1500

リザーバータンクからターゲットに連続して薬液を注入するためのインフュージョンポンプ。

Kobayashi M, Kiyono Y, Maruyama R, Mori T, Kawai K and Okazawa H. Journal of Cerebral Blood Flow & Metabolism, (28 July 2010) doi:10.1038/jcbfm.2010.122 Development of an H215O steady-state method combining a bolus and slow increasing injection with a multiprogramming syringe pump. (本文献中のFP-2000はFP-2100の旧型機です。)

学習・記憶・行動科学シャトルアボイダンス

MSB-002 / MSB-001 / SG-300 / MBX-010 / MBX-002

シャトル型2ウェイケージを用いて条件刺激に対する回避、逃避の反応率を測定します。

Continuous Activation of Renin-Angiotensin System Impairs Cognitive Function in Renin/Angiotensinogen Transgenic Mice
Shinji Inaba, Masaru Iwai, Megumi Furuno, Yumiko Tomono, Harumi Kanno, Izumi Senba, Hideki Okayama, Masaki Mogi, Jitsuo Higaki, Masatsugu Horiuchi

Angiotensin II Type-2 Receptor Stimulation Prevents Neural Damage by Transcriptional Activation of Methyl Methanesulfonate Sensitive 2
Masaki Mogi, Jian-Mei Li, Jun Iwanami, Li-Juan Min, Kana Tsukada, Masaru Iwai and Masatsugu Horiuchi

Involvement of GABA receptor systems in action of antidepressants II: Baclofen attenuates the effect of desipramine whereas muscimol has no effect in learned helplessness paradigm in rats
Yutaka Nakagawa, Tsuyoshi Ishima, Yoshinori Ishibashi, Minoru Tsuji, Toshiyuki Takashima

学習・記憶・行動科学コミュニケーションボックス(小川方式) CBシリーズ

CB3 / CB5 / CB6 / CB8

電撃をうける動物と、それを観察する動物を、実験で実現します。純心理的な社会ストレス・情動の研究に、ぜひご利用ください。

Uehara T, Sumiyoshi T, Itoh H, Kurachi M. Psychopharmacology (Berl). 2007 Dec;195(2):297-302.
Role of glutamate transporters in the modulation of stress-induced lactate metabolism in the rat brain.

Uehara T, Sumiyoshi T, Matsuoka T, Itoh H, Kurachi M. Psychopharmacology (Berl). 2006 Jun;186(2):218-25.
Role of 5-HT(1A) receptors in the modulation of stress-induced lactate metabolism in the medial prefrontal cortex and basolateral amygdala.

Uehara T, Sumiyoshi T, Itoh H, Kurachi M. Brain Res. 2003 Oct 31;989(1):112-6.
Modulation of stress-induced dopamine release by excitotoxic damage of the entorhinal cortex in the rat.

回転かご式自発運動量測定マウス用 回転かご RWC-15

RWC-15

高圧蒸気滅菌【オートクレーブ】対応。通常マウスはもちろんのこと、肥満マウス、運動機能の低下した動物、幼若マウス、老齢マウスも無理なく使用できる構造です。

Impaired social facilitation on voluntary exercise of BALB/cCrSlc mice, a proposed as an autism spectrum disorder model
Kaichi Yoshizaki, Masato Asai, Atsuno Nakayama(2020)

Cinnamic acid shortens the period of the circadian clock in mice.
Oishi K, Yamamoto S, Oike H, Ohkura N, Taniguchi M (2017)

Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects.
Oishi K, Yasumoto Y, Higo-Yamamoto S, Yamamoto S, Ohkura N (2017)

Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice.
Yasumoto Y, Hashimoto C, Nakao R, Yamazaki H, Hiroyama H, Nemoto T, Yamamoto S, Sakurai M, Oike H, Wada N, Yoshida-Noro C, Oishi K. (2016)

Disrupted light-dark cycle abolishes circadian expression of peripheral clock genes without inducing behavioral arrhythmicity in mice.
Oishi K, Higo-Yamamoto S, Yamamoto S, Yasumoto Y.(2015)

Muscle Weakness and Fibrosis Due to Cell Autonomous and Non-cell Autonomous Events in Collagen VI Deficient Congenital Muscular Dystrophy
Satoru Noguchi, Megumu Ogawa, May Christine Malicdan, Ikuya Nonaka, Ichizo Nishino (2017)

Sialyllactose ameliorates myopathic phenotypes in symptomatic GNE myopathy model mice.
Yonekawa T, Malicdan MC, Cho A, Hayashi YK, Nonaka I, Mine T, Yamamoto T, Nishino I, Noguchi S.(2014)

Dietary heat-killed Lactobacillus brevis SBC8803 promotes voluntary wheel-running and affects sleep rhythms in mice
Koyomi Miyazaki, Nanako Itoh, Saori Yamamoto, Sayaka Higo-Yamamoto, Yasukazu Nakakita,
Hirotaka Kaneda, Tatsuro Shigyo, Katsutaka Oishi. (2014)

Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice.
Katsutaka Oishi, Morichika Konishi, Yusuke Murata, Nobuyuki Itoh.(2012)

Sujino M, et al.
Current Biology 2003:13:664-668.
Suprachiasmaticnucleus grafts restore circadian behavioral rhythms of genetically arrythmic mice.

Sujino M et al.
European J. Neruoscience 2007:26:2731-2738.
Temporal profile of circadian clock gene expression in a transplanted suprachiasmatic nucleus and peripheral tissues.

上記論文に使用されている回転かごSWシリーズ、RWシリーズはニューモデルへの移行につき販売を終了しております。同等品をご検討の場合は、ニューモデルRWC-15をお求めください。

給餌制限・摂餌量測定摂餌量測定装置 餌箱2個タイプ

FDM-700SW/FDM-300AW

餌の選択実験や嗜好性の試験に最適。ラット用とマウス用の2タイプをご用意しております。催吐・制吐作用の長時間測定装置としてもご利用いただけます。

Strain differences in the development of cisplatin-induced pica behavior in mice
Journal of Pharmacological and Toxicological Methods Volume 91, May-June 2018, Pages 66-71
Kouichi Yamamotoa, Atsushi Yamatodani
Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan

Induction and antagonism of pica induced by teriparatide in rats
European Journal of Pharmacology 764(2015)457-462
Yamamoto K, Kato N, Isogai Y, Kuroda T, Ishida T, Yamatodani A
Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan.

Involvement of substance P in the development of cisplatin-induced acute and delayed pica in rats
British Pharmacological Society 2014 Feb 12. DOI: 10.1111/bph.12629
Yamamoto K, Asano K, Tasaka A, Ogura Y, Kim S, Ito Y, Yamatodani A.
Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Time-course analysis of pica in rats using an automatic feeding monitoring system
Journal of Pharmacological and Toxicological Methods 2011;63(1):30-34.
Yamamoto K, Asano K, Matsukawa N, Imaizumi M and Yamatodani A.
Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

Methotrexate causes a change in intestinal 5-hydroxytryptamine metabolism in rats
Eur J Pharmacol. 2014 Oct 5;740:496-503. doi: 10.1016/j.ejphar.2014.06.038. Epub 2014 Jun 27.
Takano Y, Machida T, Obara Y, Hirano M, Kudo S, Takagi M, Hamaue N, Iizuka K, Hirafuji M.
Departments of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan.

Involvement of hypothalamic cyclooxygenase-2, interleukin-1βand melanocortin in the development of docetaxel-induced anorexia in rats
Toxicology. doi:10.1016/j.tox.2012.07.015
Kouichi Yamamoto, Keiko Asano, Yui Ito, Naoki Matsukawa, Seikou Kim, Atsushi Yamatodani
Laboratory of Pharmacology, Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka, Japan

給餌制限・給餌量測定食餌行動解析システム(摂餌量測定装置 高精度重量センサータイプ)

cFDM-300ASH+Feedam-BM

Peptide YY induces characteristic meal patterns of aged mice
Horm Behav. 2017 Nov;96:62-68. doi: 10.1016/j.yhbeh.2017.09.003.
Mogami S, Yamada C, Fujitsuka N, Hattori T.
Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan.

Psychological stress exposure to aged mice causes abnormal feeding patterns with changes in the bout number.
Aging (Albany NY). 2017 Nov 9;9(11):2269-2287. doi: 10.18632/aging.101320.
Yamada C, Mogami S, Hattori T
Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan.

回転かご式自発運動量測定睡眠障害モデルマウス作製装置

SW-15-SD

ストレスによる睡眠障害モデルマウスを作製することに特化した特殊な飼育ケージ【特許第5975481号】。あらかじめ標準のライニングホイール付飼育ケージで順化させた後、この特殊ケージに移すと、睡眠リズムの乱れが生じ、1日の行動リズムへの変調も引き起こします。

Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit
Yasunobu Arima, Takuto Ohki, Naoki Nishikawa, Kotaro Higuchi, Mitsutoshi Ota

Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice.
Oishi K, Ohyama S, Higo-Yamamoto S (2018)

Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer’s disease model mice
Eriko N.Minakawa, Koyomi Miyazaki, Kazushi Maruo, Hiroko Yagihara, Hiromi Fujita, Keiji Wada, Yoshitaka Nagai (2017)

Disruption of behavioral circadian rhythms induced by psychophysiological stress affects plasma free amino acid profiles without affecting peripheral clock gene expression in mice
Katsutaka Oish, Saori Yamamoto, Nanako Itoh, Koyomi Miyazaki,Tadashi Nemoto, Yasukazu Nakakita, Hirotaka Kaneda. (2014)

給餌制限・摂餌量測定マウス用コントローラー一体型タイプ

FDM-300

The effects of bilateral lesions of the mesencephalic trigeminal sensory nucleus on nocturnal feeding and related behaviors in mice.
Life Sciences 93 (2013) 681-686.
Sanae Yokoyama, Ken-ichi Kinoshita, Yoshikage Muroi, Toshiaki Ishii.
Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.

Time-of-day and nutrients in feeding govern daily expression rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liver.
J Biol. Chem. 2010;285(43):33028-33036.
Matsumoto E, Ishihara A, Tamai S, Nemoto A, Iwase K, Hiwasa T, Shibata S and Takiguchi M.
Department of Biochemistry and Genetics, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chiba 260-8670 and the Department of Pharmacology, School of Science and Engineering, Waseda University, Wakamatsu-cho 2-2, Shinjuku-ku 162-8480, Japan

High-salt diet advances molecular circadian rhythms in mouse peripheral tissues.
Biochem. Biophys. Res. Com. 2010;402(1):7-13.
Oike H, Nagai K, Fukushima T, Ishida N and Kobori M.
Food Function Division, National Food Research Institute (NFRI), National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki 305-8642, Japan

給餌制限・摂餌量測定ラット用コントローラー一体型タイプ

FDM-700A

Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: Validation with olanzapine and ziprasidone.
Behav. Brain Res. 2011;216(2):561-568.
Shobo M, Yamada H, Mihara T, Kondo Y, Irie M, Harada K, Ni K, Matsuoka N and Kayama Y.
Pharmacology Research Labs, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan

回転かご式自発運動量測定、給餌制限・摂餌量測定回転かご付摂餌量測定装置

cFDM-300SS-SW

特許取得済み製品『Feedam シリーズ』に回転かごがつきました。摂餌行動とエクササイズの研究にご利用いただけます。

行動解析行動解析装置 SCANET-40シリーズ

MV-40 / SV-40 / CV-40

高密度に配置した赤外線センサーを用いて、マウス・ラットの行動解析を行う装置です。1台の装置で、自発運動量、薬物依存作用や抗不安、学習記憶テスト、抗うつスクリーニングテスト、恐怖条件付け実験など10個以上の実験モードに対応しているため、実験毎に測定装置を買い揃える必要がありません。

Tashiro T, Murakami Y, Mouri A, Imamura Y, Nabeshima T, Yamamoto Y, Saito K.
Behav Brain Res. 2017 Jan 15;317:279-285. doi: 10.1016/j.bbr.2016.09.050.  PMID: 27693848
Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.

Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K.
Sci Rep. 2016 Jul 20;6:29920. doi: 10.1038/srep29920. PMID: 27436416
Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1.

Tomoaki Tezuka, Makoto Tamura, Mari A.Kondo, Masaki Sakaue, Kinya Okada, Kana Takemoto, Atsuhi Fukunari, Keiko Miwa, Hiromitsu Ohzeki, Shin-ichi Kano, Hiroshi Yasumatsu, Akira Sawa,Yasushi Kajii
Neurobiol Dis. 2013 Nov; 59: 63-68. Published online 2013 Jul 16. doi:  10.1016/j.nbd.2013.07.003
Cuprizone short-term exposure: astrocytic IL-6 activation and behavioral changes relevant to psychosis

Munehisa Shinozaki, Akimasa Yasuda, Satoshi Nori, Nobuhito Saito, Yoshiaki Toyama, Hideyuki Okano, and Masaya Nakamura
Neurologia medico-chirurgica., Oct 2013; doi: 10.2176/nmc.tn2012-0223
Novel Method for Analyzing Locomotor Ability After Spinal Cord Injury in Rats:Technical Note
※SCANET用速度・加速度算出ソフトウェアVAC-SCL-40を使用

M. Shinozaki, Y. Takahashi, M. Mukaino, N. Saito, Y. Toyama, H Okano and M. Nakamura.
J. Biomed. Biotechnol. 2011;2011:157458.
Novel Concept of Motor Functional Analysis for Spinal Cord Injury in Adult Mice.

M. Shobo, Y. Kondo, H. Yamada, T. Mihara, N. Yamamoto, M. Katsuoka, K. Harada, K. Ni, and N. Matsuoka
J. Pharmacol. Exp. Ther., Jun 2010; 333: 772 – 781.
Norzotepine, a Major Metabolite of Zotepine, Exerts Atypical Antipsychotic-Like and Antidepressant-Like Actions through Its Potent Inhibition of Norepinephrine Reuptake

Yoshitake Sano, Veravej G. Ornthanalai, Kazuyuki Yamada, Chihiro Homma, Hitomi Suzuki, Toshiharu Suzuki, Niall P. Murphy, and Shigeyoshi Itohara
J. Neurosci., May 2009; 29: 5884 – 5896.
X11-Like Protein Deficiency Is Associated with Impaired Conflict Resolution in Mice

Katsuya Morita, Naoyo Motoyama, Tomoya Kitayama, Norimitsu Morioka, Koki Kifune, and Toshihiro Dohi
J. Pharmacol. Exp. Ther., Aug 2008; 326: 633 – 645.
Spinal Antiallodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice

Hironao Nakayama, Kiyoyuki Kitaichi, Yukiko Ito, Katsunori Hashimoto, Kenji Takagi, Toyoharu Yokoi, Kenzo Takagi, Norio Ozaki, Tuneyuki Yamamoto et al.
Brain Res., Dec 2007; 1184: 260 – 269.
The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats

Norimasa Taniguchi and Shigeyuki Kanai
Evid. Based Complement. Altern. Med., Mar 2007; 4: 99 – 105.
Efficacy of Static Magnetic Field for Locomotor Activity of Experimental Osteopenia

Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, Yasutomo Ito, Yukihiro Noda, Taku Nagai, and Toshitaka Nabeshima
J. Neurosci., Jul 2007; 27: 7604 – 7615.
A Novel Molecule “Shati” Is Involved in Methamphetamine-Induced Hyperlocomotion, Sensitization, and Conditioned Place Preference

Takafumi Shirakawa, Kenji Nakano, Naomi S. Hachiya, Nobumasa Kato, Kiyotoshi Kaneko
Neurosci Res,2007; 59: 117-23.
Temporospatial patterns of COX-2 expression and pyramidal cell degeneration in the rat hippocampus after trimethyltin administration.

A Matsumoto, Y Okada, M Nakamichi, M Nakamura, Y Toyama, G Sobue, M Nagai, M Aoki, Y Itoyama, and H Okano
J Neurosci Res, Jan 2006; 83(1): 119-33.
Disease progression of human SOD1 (G93A) transgenic ALS model rats.

Li-Bo Zou, Akihiro Mouri, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang, Min-Wei Wang, Hiroyuki Mizoguchi, Yukihiro Noda, and Toshitaka Nabeshima
J. Pharmacol. Exp. Ther., Apr 2006; 317: 334 – 340.
Inhibition of Neprilysin by Infusion of Thiorphan into the Hippocampus Causes an Accumulation of Amyloid b and Impairment of Learning and Memory

Y Yamaguchi, H Miyashita, H Tsunekawa, A Mouri, H-C Kim, K Saito, T Matsuno, S Kawashima, and T Nabeshima
J. Pharmacol. Exp. Ther., Jun 2006; 317: 1079 – 1087.
Effects of a Novel Cognitive Enhancer, Spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on Learning Impairments Induced by Amyloid-b1-40 in the Rat

Kiyoyuki Kitaichi, , Masaya Fukuda, Hironao Nakayama, Nagisa Aoyama, Yukiko Ito, Yohei Fujimoto, Kenji Takagi, Kenzo Takagi and Takaaki Hasegawa
Neurosci. Lett., July 2005; 382: 195 – 200.
Behavioral changes following antisense oligonucleotide-induced reduction of organic cation transporter-3 in mice

Takatoshi Murase, Satoshi Haramizu, Akira Shimotoyodome, Azumi Nagasawa, and Ichiro Tokimitsu
Am J Physiol Regulatory Integrative Comp Physiol, Mar 2005; 288: R708 – R715.
Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice

Yoshiaki Miyamoto, Ling Chen, Masahiro Sato, Masahiro Sokabe, Toshitaka Nabeshima, Tony Pawson, Ryuichi Sakai, and Nozomu Mori
J. Neurosci., Feb 2005; 25: 1826 – 1835.
Hippocampal Synaptic Modulation by the Phosphotyrosine Adapter Protein ShcC/N-Shc via Interaction with the NMDA Receptor

T MAMIYA, T MATSUMURA, and M UKAI
Ann. N.Y. Acad. Sci., Oct 2004; 1025: 424 – 429.
Effects of L-745,870, a Dopamine D4 Receptor Antagonist, on Naloxone-Induced Morphine Dependence in Mice

Norimasa Taniguchi, Shigeyuki Kanai, Masazumi Kawamoto, Hiroshi Endo, and Hideaki Higashino
Evid. Based Complement. Altern. Med., Sep 2004; 1: 187 – 191.
Study on Application of Static Magnetic Field for Adjuvant Arthritis Rats

Takanori Akagi, Kazami Ushinohama, Shoko Ikesue, Eiji Yukawa, Shun Higuchi, Kenji Hamase, Kiyoshi Zaitsu, and Shigehiro Ohdo
J. Pharmacol. Exp. Ther., Jan 2004; 308: 378.
Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect

Hiroyuki Mizoguchi, Kiyofumi Yamada, Makoto Mizuno, Tomoko Mizuno, Atsumi Nitta, Yukihiro Noda, and Toshitaka Nabeshima
Mol. Pharmacol., May 2004; 65: 1293 – 1301.
Regulations of Methamphetamine Reward by Extracellular Signal-Regulated Kinase 1/2/ets-Like Gene-1 Signaling Pathway via the Activation of Dopamine Receptors

K Shimosato and S Watanabe
J Neurosci Methods, Sep 2003; 128(1-2): 103-10.
Concurrent evaluation of locomotor response to novelty and propensity toward cocaine conditioned place preference in mice.

Y Mikami, M Toda, M Watanabe, M Nakamura, Y Toyama, and Y Kawakami
J Neurosurg, Jul 2002; 97(1 Suppl): 142-7.
A simple and reliable behavioral analysis of locomotor function after spinal cord injury in mice. Technical note.

Yoshiaki Miyamoto, Kiyofumi Yamada, Yukihiro Noda, Hisashi Mori, Masayoshi Mishina, and Toshitaka Nabeshima
J. Neurosci., Mar 2002; 22: 2335.
Lower Sensitivity to Stress and Altered Monoaminergic Neuronal Function in Mice Lacking the NMDA Receptor e4 Subunit

Satoru Koyanagi and Shigehiro Ohdo
Mol. Pharmacol., Dec 2002; 62: 1393.
Alteration of Intrinsic Biological Rhythms during Interferon Treatment and Its Possible Mechanism

oshiaki Miyamoto, Kiyofumi Yamada, Yukihiro Noda, Hisashi Mori, Masayoshi Mishina, and Toshitaka Nabeshima
J. Neurosci., Jan 2001; 21: 750.
Hyperfunction of Dopaminergic and Serotonergic Neuronal Systems in Mice Lacking the NMDA Receptor e1 Subunit

Oliver Stork, Simone Stork, Hans-Christian Pape, and Kunihiko Obata
Learn. Mem., Jul 2001; 8: 209 – 219.
Identification of Genes Expressed in the Amygdala During the Formation of Fear Memory

K Shimosato, S Watanabe, and S Kitayama
Naunyn Schmiedebergs Arch Pharmacol, Jul 2001; 364(1): 74-80.
Differential effects of trihexyphenidyl on place preference conditioning and locomotor stimulant activity of cocaine and methamphetamine.

K Kobayashi, Y Noda, N Matsushita, K Nishii, H Sawada, T Nagatsu, D Nakahara, R Fukabori, Y Yasoshima, T Yamamoto, M Miura, M Kano, T Mamiya, Y Miyamoto, and T Nabeshima
J. Neurosci., Mar 2000; 20: 2418.
Modest Neuropsychological Deficits Caused by Reduced Noradrenaline Metabolism in Mice Heterozygous for a Mutated Tyrosine Hydroxylase Gene

Mayumi Yamano, Hidenobu Yuki, Syuhei Yasuda, and Keiji Miyata
J. Pharmacol. Exp. Ther., Jan 2000; 292: 181.
Corticotropin-Releasing Hormone1 Receptors Mediate Consensus Interferon-a YM643-Induced Depression-Like Behavior in Mice

K Shimosato and S Ohkuma
Pharmacol Biochem Behav, Jun 2000; 66(2): 285-92.
Simultaneous monitoring of conditioned place preference and locomotor sensitization following repeated administration of cocaine and methamphetamine.

Y Oike, A Hata, T Mamiya, T Kaname, Y Noda, M Suzuki, H Yasue, T Nabeshima, K Araki, and K Yamamura
Hum. Mol. Genet., Mar 1999; 8: 387 – 396.
Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism

Hiroko Ohki-Hamazaki, Yasushi Sakai, Katsuo Kamata, Hiroo Ogura, Shigeru Okuyama, Kei Watase, Kazuyuki Yamada, and Keiji Wada
J. Neurosci., Feb 1999; 19: 948.
Functional Properties of Two Bombesin-Like Peptide Receptors Revealed by the Analysis of Mice Lacking Neuromedin B Receptor

Yukihiro Noda, Takayoshi Mamiya, Toshitaka Nabeshima, Miyuki Nishi, Masaya Higashioka, and Hiroshi Takeshima
J. Biol. Chem., Jul 1998; 273: 18047.
Loss of Antinociception Induced by Naloxone Benzoylhydrazone in Nociceptin Receptor-Knockout Mice

Yukihiro Noda, Yoshiaki Miyamoto, Takayoshi Mamiya, Hiroyuki Kamei, Hiroshi Furukawa, and Toshitaka Nabeshima
J. Pharmacol. Exp. Ther., Jul 1998; 286: 44.
Involvement of Dopaminergic System in Phencyclidine-Induced Place Preference in Mice Pretreated with Phencyclidine Repeatedly

Masayuki Hiramatsu, Hiroyasu Murasawa, Toshitaka Nabeshima, and Tsutomu Kameyama
J. Pharmacol. Exp. Ther., Mar 1998; 284: 858.
Effects of U-50,488H on Scopolamine-, Mecamylamine- and Dizocilpine-Induced Learning and Memory Impairment in Rats

ベルト式強制走行装置マウス・ラット用トレッドミルシステム

TMS-10N/TMS-8N/TMS-6N/TMS-4N/TMS-2N

マウス或いはラット複数匹を同時に強制走行させるためのベルト式装置です。

Exercise Ameliorates Emphysema Of Cigarette Smoke-Induced COPD In Mice Through The Exercise-Irisin-Nrf2 Axis
Hiroaki Kubo, Kazuhisa Asai, Kazuya Kojima, Arata Sugitani, Yohkoh Kyomoto, Atsuko Okamoto, Kazuhiro Yamada, Naoki Ijiri, Tetsuya Watanabe, Kazuto Hirata and Tomoya Kawaguchi(2019)

Glucose prevents cisplatin-induced fatigue-like behavior in mice
Kazumi Yoshizawa, Aoi Yamane,Haruka Nasu and Hidetaka Suzuki (2018)

Treadmill exercise induces murine caediac allograft survival and generates regulatory T cell
Uchiyama M, Jin X, Yin E, Shimokawa T and Niimi M (2015)

Impaired arterial pressure regulation during excercise due to enhanced muscular vasodilatation in calponin knockout mice
Shizue Masuki, Michiko Takeoka, Shun’ichiro Taniguchi, Minesuke Yokoyama and Hiroshi Nose
J.Physiol.2003;553;203-212; originally published online Sep 8,2003;

運動量測定LOCOMO(マウス用/ラット用)

LS-5/LS-6/LS-7/LS-8/LS-8MV

市販の飼育ケージを設置することで、動物の運動量を測定できます。薬物の作用や遺伝子改変による行動量の変化を見るのに最適です。

Negative rebound in hippocampal neurogenesis following exercise cessation.pdf
Takeshi Nishijima, Yoshika Kamidozono, Atsushi Ishiizumi, Seiichiro Amemiya, and Ichiro Kita

Ameliorative effects of yokukansan on behavioral deficits in a gerbil model of global cerebral ischemia
Yanan Liu, Takehiro Nakamura, Tetsuhiko Toyoshima, Feng Lu, Kazunori Sumitani, Aya Shinomiya, Rchad F. Keep, Tohru Yamamoto, Takashi Tamiya, Toshifumi Itano
Brain Research I543(2014) 300-307.

Shim S and Tanaka H. Physiol Behav. 2000;71(5):477-83. Effects of restricted food access on circadian fluctuation of serotonin N-acetyltransferase activities in hereditary microphthalmic rats.

Masuki S, Todo T, Nakano Y, Okamura H and Nose H. J. Physiol. 2005;566(1):213-224. Reduced α-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock.

Niimi K, Takahashi E and Itakura C. Experimental Gerontology 2008;43(9):847-852. Improved short-term memory and increased expression of NR2B observed in senescence-accelerated mouse (SAM) P6.

Niimi K, Takahashi E and Itakura C. Physiol Behav. 2009;96(3):464-469. Analysis of motor function and dopamine systems of SAMP6 mouse

Masuki S and Nose H. J. Physiol. 2009;587(23):5783-5794. Increased cerebral activity suppresses baroreflex control of heart rate in freely moving mice.

Niimi K, Takahashi E, and Itakura C. Brain Res. 2009;1250(23):175-182. Age dependence of motor activity and sensitivity to dopamine receptor 1 agonist, SKF82958, of inbred AKR/J, BALB/c, C57BL/6J, SAMR1, and SAMP6 strains.

Niimi K and Takahashi E. Neurosci. Lett. 2009;458(2):53-56. Combination of modified SHIRPA and pharmacological approach uncovers neuronal alteration in senescence-accelerated mouse prone 6 (SAMP6) strain.

akamura T, Tanaka S, Hirooka K, Toyoshima T, Kawai N, Tamiya T, Shiraga F, Tokuda M, Keep RF, Itano T and Miyamoto O. Neurosci. Lett. 2011;487(1,3):103-106. Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat.

Yoshiko Nakae, Olivier M.Dochies, Peter J. Stoward, Benno F. Zimmermann, Christina Ritter, Urs T. Ruegg Histochem Cell Biol 2012:137:811-827 Quantitative evaluation of the beneficial effects in the max mouse of epigallocatechin gallate, an antioxidant polyphenol from green tea.

運動量測定運動量センサー(回転かご、LOCOMO以外)

熱感知式運動量センサー(AS-10シリーズ)

飲水量測定ドリンクモニターシステム

DS-30

小動物の飲水に応じて、給水ボトルから給水ノズルへの液体の滴下数を ビームセンサーでカウントします。

Satoh Y, Ishizuka K and Murakami T. J. Oral Biosci. 2008;50(3):200-206. Effects of lesions of the red nucleus on feeding and drinking in rats.